@article{blanquart_properties_2014,
Author = {Blanquart, François and Achaz, Guillaume and
Bataillon, Thomas and Tenaillon, Olivier},
Title = {Properties of selected mutations and genotypic
landscapes under {Fisher}’s {Geometric} {Model}},
Journal = {Evolution; international journal of organic evolution},
Volume = {68},
Number = {12},
Pages = {3537--3554},
abstract = {The fitness landscape – the mapping between
genotypes and fitness – determines properties of the
process of adaptation. Several small genotypic fitness
landscapes have recently been built by selecting a
handful of beneficial mutations and measuring fitness
of all combinations of these mutations. Here we
generate several testable predictions for the
properties of these small genotypic landscapes under
Fisher’s geometric model of adaptation. When the
ancestral strain is far from the fitness optimum, we
analytically compute the fitness effect of selected
mutations and their epistatic interactions. Epistasis
may be negative or positive on average depending on the
distance of the ancestral genotype to the optimum and
whether mutations were independently selected, or
co-selected in an adaptive walk. Simulations show that
genotypic landscapes built from Fisher’s model are
very close to an additive landscape when the ancestral
strain is far from the optimum. However, when it is
close to the optimum, a large diversity of landscape
with substantial roughness and sign epistasis emerged.
Strikingly, small genotypic landscapes built from
several replicate adaptive walks on the same underlying
landscape were highly variable, suggesting that several
realizations of small genotypic landscapes are needed
to gain information about the underlying architecture
of the fitness landscape.},
doi = {10.1111/evo.12545},
issn = {0014-3820},
month = dec,
pmcid = {PMC4326662},
pmid = {25311558},
url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326662/},
urldate = {2015-04-13},
year = 2014
}