SMILE

Stochastic Models for the Inference of Life Evolution

Bibtex

@article{ferretti_effect_2013,
Author = {Ferretti, Luca and Disanto, Filippo and Wiehe, Thomas},
Title = {The effect of single recombination events on
coalescent tree height and shape},
Journal = {PloS One},
Volume = {8},
Number = {4},
Pages = {e60123},
abstract = {The coalescent with recombination is a fundamental
model to describe the genealogical history of DNA
sequence samples from recombining organisms.
Considering recombination as a process which acts along
genomes and which creates sequence segments with shared
ancestry, we study the influence of single
recombination events upon tree characteristics of the
coalescent. We focus on properties such as tree height
and tree balance and quantify analytically the changes
in these quantities incurred by recombination in terms
of probability distributions. We find that changes in
tree topology are often relatively mild under
conditions of neutral evolution, while changes in tree
height are on average quite large. Our results add to a
quantitative understanding of the spatial coalescent
and provide the neutral reference to which the impact
by other evolutionary scenarios, for instance tree
distortion by selective sweeps, can be compared.},
doi = {10.1371/journal.pone.0060123},
issn = {1932-6203},
language = {eng},
pmcid = {PMC3620475},
pmid = {23593168},
year = 2013
}