SMILE

Stochastic Models for the Inference of Life Evolution

Variation in the major surface glycoprotein genes in Pneumocystis jirovecii

Kutty, G., Maldarelli, F., Achaz, G., Kovacs, J. A.

The Journal of Infectious Diseases

2008

The genome of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface glycoprotein (Msg). Pneumocystis can vary the expressed Msg, presumably as a mechanism to avoid host immune responses. Analysis of 24 msg-gene sequences obtained from a single human isolate of Pneumocystis demonstrated that the sequences segregate into 2 branches. Results of a number of analyses suggest that recombination between msg genes is an important mechanism for generating msg diversity. Intrabranch recombination occurred more frequently than interbranch recombination. Restriction-fragment length polymorphism analysis of human isolates of Pneumocystis demonstrated substantial variation in the repertoire of the msg-gene family, variation that was not observed in laboratory isolates of Pneumocystis in rats or mice; this may be the result of examining outbred versus captive populations. Increased diversity in the Msg repertoire, generated in part by recombination, increases the potential for antigenic variation in this abundant surface protein.

Bibtex

@article{kutty_variation_2008,
Author = {Kutty, Geetha and Maldarelli, Frank and Achaz,
Guillaume and Kovacs, Joseph A.},
Title = {Variation in the major surface glycoprotein genes in
{Pneumocystis} jirovecii},
Journal = {The Journal of Infectious Diseases},
Volume = {198},
Number = {5},
Pages = {741--749},
abstract = {The genome of Pneumocystis, which causes
life-threatening pneumonia in immunosuppressed
patients, contains a multicopy gene family that encodes
the major surface glycoprotein (Msg). Pneumocystis can
vary the expressed Msg, presumably as a mechanism to
avoid host immune responses. Analysis of 24 msg-gene
sequences obtained from a single human isolate of
Pneumocystis demonstrated that the sequences segregate
into 2 branches. Results of a number of analyses
suggest that recombination between msg genes is an
important mechanism for generating msg diversity.
Intrabranch recombination occurred more frequently than
interbranch recombination. Restriction-fragment length
polymorphism analysis of human isolates of Pneumocystis
demonstrated substantial variation in the repertoire of
the msg-gene family, variation that was not observed in
laboratory isolates of Pneumocystis in rats or mice;
this may be the result of examining outbred versus
captive populations. Increased diversity in the Msg
repertoire, generated in part by recombination,
increases the potential for antigenic variation in this
abundant surface protein.},
doi = {10.1086/590433},
issn = {0022-1899},
language = {eng},
month = sep,
pmcid = {PMC2561252},
pmid = {18627244},
year = 2008
}

@InCollection{lambert_vers_2014,
Author = {Lambert, Amaury},
Title = {Vers une approche formelle des origines évolutives de
la simplexité ?},
BookTitle = {Complexité-{Simplexité}},
Publisher = {Collège de France},
Editor = {Petit, Jean-Luc and Berthoz, Alain},
Series = {Conférences},
Address = {Paris},
isbn = {978722603303301},
month = mar,
url = {http://books.openedition.org/cdf/3361},
urldate = {2014-07-23},
year = 2014
}

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