guillaume.achaz@mnhn.fr
Catch me if you can:
CdF: +33-1-44-27-13-91
MNHN: +33-1-40-79-57-68

Positions
Professor at Université Paris-Cité
Co-head of research group SMILE (Collège de France)
Director of the GDR network AIEM (CNRS)
Lecturer in population genetics (Ecole Normale Supérieure)
affiliated to research group Anthropologie génétique (Musée de l'Homme)
affiliated to research group Atelier de BioInformatique (Muséum)

Interests in Biology

Keywords

Theoretical Biology, Molecular Evolution, Bioinformatics.

Mindset

Adaptation

I have been working on properties of fitness landscapes. We are trying to characterize the models that fits the best experimental fitness landscapes. We also have developped a tool to explore visually fitness landscapes, that is accessible from the Magellan webpage. In the last years, we have been working on detecting and characterizing correlated evolution using a phylogenetic approach Related softwares are Epics and Epocs.

Coalescent Theory

 I have developped tests for neutrality related to the famous Tajima's D. In an attempt to correct for sequencing errors, I built new tests that exclude singletons. I also have also develop a unifying framework that encompasses all neutrality tests based on the frequency spectrum and makes easy the creation of new ones. To compute these new tests (and the previous ones), please visit the online neutrality tests. I also did some work on the SFS decomposition and on alternative models to that generate U-shaped SFS.

Species Delineation

I worked on a method that delineate species from a genetic dataset (aligned sequences) and propose partitions into a priori species. The method was develop in collaboration with N Puilandre (MNHN), A Lambert (UPMC, UFR Maths) and S Brouillet (ABI). The Automatic Barcod Gap Discovery method (ABGD) can be used from here. A new (2021) software, ASAP is accessible from here.

Conservation

 I am currently working on methods to assess very recent demography using information from linkage disiquilibrium.

Publications

• You can retrieve my scientific publications from PubMed or from Google scholar
• PhD thesis: Etude de la dynamique des génomes : les répétitions intrachromosomiques
• HDR : Evolution moléculaire : des données aux modèles, et vice-versa

Main Lectures

• Basics in mathematics (Bachelor)
• Bioinformatics (Master)
• Population genetics (Bachelor and Master). French readers interested in an introductory text in coalescent theory could cast a glance coalescence.pdf.

Where and when

• 2019-now : professor (Univ Paris-Cité).
• 2009-2010: delegation CNRS (sabbatical at Kyoto Univ).
• 2005-2019 : maître de conférences (UPMC / Sorbonne Université).
• 2005         : bioinformatics engineering (Modul-Bio, Marseille).
  
• 2002-2005: postdoc with John Wakeley (Harvard University).
  
• 1999-2002: PhD with Eric Coissac & Pierre Netter (UPMC ; IJM).